Glucosamine-phosphate N-acetyltransferase

Thus, the two substrates of this enzyme are acetyl-CoA and D-glucosamine 6-phosphate, whereas its two products are CoA and N-acetyl-D-glucosamine 6-phosphate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups.^[1] The systematic name of this enzyme class is acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase. Other names in common use include phosphoglucosamine transacetylase, phosphoglucosamine acetylase, glucosamine-6-phosphate acetylase, D-glucosamine-6-P N-acetyltransferase, aminodeoxyglucosephosphate acetyltransferase, glucosamine 6-phosphate acetylase, glucosamine 6-phosphate N-acetyltransferase, N-acetylglucosamine-6-phosphate synthase, phosphoglucosamine N-acetylase, glucosamine-phosphate N-acetyltransferase, and glucosamine-6-phosphate N-acetyltransferase. This enzyme participates in glutamate metabolism and aminosugars metabolism.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1I12, 1I1D, 1I21, 2HUZ, and 2O28.

References

↑ Ma Y, Ghoshdastider U, Wang J, Ye W, DötschV, Filipek S, Bernhard F, Wang X (2012). "Cell-free expression of human Glucosamine 6-phosphate N-acetyltransferase (HsGNA1) for inhibitor screening.". Protein Expres Purif. 86 (2): 120–126. doi:10.1016/j.pep.2012.09.011. PMID 23036358.

Davidson EA; Blumenthal, HJ; Roseman, S (1966). "Glucosamine 6-phosphate N-acetylase". Methods Enzymol. 9 (1): 704–707. doi:10.1016/0076-6879(66)09142-0.
DAVIDSON EA, BLUMENTHAL HJ, ROSEMAN S (1957). "Glucosamine metabolism. II. Studies on glucosamine 6-phosphate N-acetylase". J. Biol. Chem. 226 (1): 125–33. PMID 13428743.
PATTABIRAMAN TN, BACHHAWAT BK (1962). "Purification of glucosamine-6-phosphate N-acetylase from sheep brain". Biochim. Biophys. Acta. 59 (3): 681–9. doi:10.1016/0006-3002(62)90648-0. PMID 14484387.
Hui CC, Chung S, Huber LA, Mak TW, Iscove NN (2000). "Cloning and characterization of the murine glucosamine-6-phosphate acetyltransferase EMeg32. Differential expression and intracellular membrane association". J. Biol. Chem. 275 (17): 12821–32. doi:10.1074/jbc.275.17.12821. PMID 10777580.

Transferases: acyltransferases (EC 2.3)

2.3.1: other than amino-acyl groups	acetyltransferases: Acetyl-Coenzyme A acetyltransferase N-Acetylglutamate synthase Choline acetyltransferase Dihydrolipoyl transacetylase Acetyl-CoA C-acyltransferase Beta-galactoside transacetylase Chloramphenicol acetyltransferase N-acetyltransferase Serotonin N-acetyl transferase HGSNAT ARD1A Histone acetyltransferase P300/CBP NAT2 palmitoyltransferases: Carnitine O-palmitoyltransferase CPT1 CPT2 Serine C-palmitoyltransferase SPTLC1 SPTLC2 other: Acyltransferase like 2 Aminolevulinic acid synthase Beta-ketoacyl-ACP synthase Glyceronephosphate O-acyltransferase Lecithin—cholesterol acyltransferase Glycerol-3-phosphate O-acyltransferase 1-acylglycerol-3-phosphate O-acyltransferase 2-acylglycerol-3-phosphate O-acyltransferase ABHD5

2.3.2: Aminoacyltransferases	Gamma-glutamyl transpeptidase Peptidyl transferase Transglutaminase Tissue transglutaminase Keratinocyte transglutaminase Factor XIII

2.3.3: converted into alkyl on transfer	Citrate synthase ATP citrate lyase HMG-CoA synthase Malate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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