Germacrene A alcohol dehydrogenase
| Germacrene A alcohol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.314 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Germacrene A alcohol dehydrogenase (EC 1.1.1.314) is an enzyme with systematic name germacra-1(10),4,11(13)-trien-12-ol:NADP+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
- germacra-1(10),4,11(13)-trien-12-ol + 2 NADP+ + H2O germacra-1(10),4,11(13)-trien-12-oate + 2 NADPH + 3 H+ (overall reaction)
- (1a) germacra-1(10),4,11(13)-trien-12-ol + NADP+ germacra-1(10),4,11(13)-trien-12-al + NADPH + H+
- (1b) germacra-1(10),4,11(13)-trien-12-al + NADP+ + H2O germacra-1(10),4,11(13)-trien-12-oate + NADPH + 2 H+
In Lactuca sativa this enzyme is a mutifunctional enzyme with EC 1.14.13.123.
References
- ↑ de Kraker, J.W.; Franssen, M.C.; Dalm, M.C.; de Groot, A.; Bouwmeester, H.J. (2001). "Biosynthesis of germacrene A carboxylic acid in chicory roots. Demonstration of a cytochrome P450 (+)-germacrene A hydroxylase and NADP+-dependent sesquiterpenoid dehydrogenase(s) involved in sesquiterpene lactone biosynthesis". Plant Physiol. 125: 1930–1940. doi:10.1104/pp.125.4.1930. PMC 88848
. PMID 11299372. - ↑ Nguyen, D.T.; Gopfert, J.C.; Ikezawa, N.; Macnevin, G.; Kathiresan, M.; Conrad, J.; Spring, O.; Ro, D.K. (2010). "Biochemical conservation and evolution of germacrene A oxidase in asteraceae". J. Biol. Chem. 285 (22): 16588–16598. doi:10.1074/jbc.M110.111757. PMC 2878029. PMID 20351109.
External links
- Germacrene A alcohol dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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