Germacradienol synthase
| Germacradienol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.3.22 | ||||||||
| CAS number | 211049-88-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Germacradienol synthase (EC 4.2.3.22, germacradienol/germacrene-D synthase, 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming]) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming).[1][2][3] This enzyme catalyses the following chemical reaction
- (2E,6E)-farnesyl diphosphate + H2O (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate
This enzyme requires Mg2+ for activity.
References
- ↑ Cane, D.E.; Watt, R.M. (2003). "Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis". Proc. Natl. Acad. Sci. USA. 100: 1547–1551. doi:10.1073/pnas.0337625100. PMID 12556563.
- ↑ He, X.; Cane, D.E. (2004). "Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2)". J. Am. Chem. Soc. 126: 2678–2679. doi:10.1021/ja039929k. PMID 14995166.
- ↑ Gust, B.; Challis, G.L.; Fowler, K.; Kieser, T.; Chater, K.F. (2003). "PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin". Proc. Natl. Acad. Sci. USA. 100 (4): 1541–1546. doi:10.1073/pnas.0337542100. PMID 12563033.
External links
- Germacradienol synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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