Gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase

Gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase
Identifiers
EC number 4.3.2.6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase (EC 4.3.2.6, btrG (gene)) is an enzyme with systematic name gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase (5-oxoproline producing).[1] This enzyme catalyses the following chemical reaction

gamma-L-glutamyl-butirosin B butirosin B + 5-oxoproline

The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B.

References

  1. Llewellyn, N.M.; Li, Y.; Spencer, J.B. (2007). "Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain". Chem. Biol. 14: 379–386. doi:10.1016/j.chembiol.2007.02.005. PMID 17462573.
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