FMN reductase (NADPH)

FMN reductase (NADPH)
Identifiers
EC number 1.5.1.38
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

FMN reductase (NADPH) (EC 1.5.1.38, FRP, flavin reductase P, SsuE) is an enzyme with systematic name FMNH2:NADP+ oxidoreductase.[1][2][3][4][5][6][7][8] This enzyme catalyses the following chemical reaction:

FMNH2 + NADP+ FMN + NADPH + H+

The enzymes from bioluminescent bacteria contain FMN.

References

  1. ↑ Gerlo, E.; Charlier, J. (1975). "Identification of NADH-specific and NADPH-specific FMN reductases in Beneckea harveyi". Eur. J. Biochem. 57 (2): 461–467. doi:10.1111/j.1432-1033.1975.tb02321.x. PMID 1175652.
  2. ↑ Jablonski, E.; DeLuca, M. (1977). "Purification and properties of the NADH and NADPH specific FMN oxidoreductases from Beneckea harveyi". Biochemistry. 16 (13): 2932–2936. doi:10.1021/bi00632a020. PMID 880288.
  3. ↑ Jablonski, E.; DeLuca, M. (1978). "Studies of the control of luminescence in Beneckea harveyi: properties of the NADH and NADPH:FMN oxidoreductases". Biochemistry. 17 (4): 672–678. doi:10.1021/bi00597a018. PMID 23827.
  4. ↑ Lei, B.; Liu, M.; Huang, S.; Tu, S.C. (1994). "Vibrio harveyi NADPH-flavin oxidoreductase: cloning, sequencing and overexpression of the gene and purification and characterization of the cloned enzyme". J. Bacteriol. 176 (12): 3552–3558. PMC 205543Freely accessible. PMID 8206832.
  5. ↑ Tanner, J.J.; Lei, B.; Tu, S.C.; Krause, K.L. (1996). "Flavin reductase P: structure of a dimeric enzyme that reduces flavin". Biochemistry. 35 (42): 13531–13539. doi:10.1021/bi961400v. PMID 8885832.
  6. ↑ Liu, M.; Lei, B.; Ding, Q.; Lee, J.C.; Tu, S.C. (1997). "Vibrio harveyi NADPH:FMN oxidoreductase: preparation and characterization of the apoenzyme and monomer-dimer equilibrium". Arch. Biochem. Biophys. 337: 89–95. doi:10.1006/abbi.1996.9746. PMID 8990272.
  7. ↑ Lei, B.; Tu, S.C. (1998). "Mechanism of reduced flavin transfer from Vibrio harveyi NADPH-FMN oxidoreductase to luciferase". Biochemistry. 37: 14623–14629. doi:10.1021/bi981841+. PMID 9772191.
  8. ↑ Eichhorn, E.; van der Ploeg, J.R.; Leisinger, T. (1999). "Characterization of a two-component alkanesulfonate monooxygenase from Escherichia coli". J. Biol. Chem. 274: 26639–26646. doi:10.1074/jbc.274.38.26639. PMID 10480865.
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