FMNL3
| FMNL3 | |||||||||||||||||
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| Identifiers | |||||||||||||||||
| Aliases | FMNL3, FHOD3, WBP-3, WBP3, FRL2, formin like 3 | ||||||||||||||||
| External IDs | MGI: 109569 HomoloGene: 69101 GeneCards: FMNL3 | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 12: 49.64 – 49.71 Mb | Chr 15: 99.32 – 99.37 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
| Wikidata | |||||||||||||||||
| View/Edit Human | View/Edit Mouse |
Formin-like protein 3 (FMNL3), also known as WW domain-binding protein 3 (WBP-3), is a protein that in humans is encoded by the FMNL3 gene.[3][4]
Function
The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described.[3] The C-terminus has been shown to accelerate actin polymerization activity of this protein through its WH2-like motif.[5] FMNL3 has been crystallized in complex with actin providing insight into the mechanism of formin-mediated actin nucleation.[6]
See also
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- 1 2 "Entrez Gene: formin-like 3".
- ↑ Katoh M, Katoh M (May 2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". International Journal of Oncology. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID 12684686.
- ↑ Heimsath EG, Higgs HN (Jan 2012). "The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends". The Journal of Biological Chemistry. 287 (5): 3087–98. doi:10.1074/jbc.M111.312207. PMC 3270965
. PMID 22094460. - ↑ Thompson ME, Heimsath EG, Gauvin TJ, Higgs HN, Kull FJ (Jan 2013). "FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation". Nature Structural & Molecular Biology. 20 (1): 111–8. doi:10.1038/nsmb.2462. PMC 3876896. PMID 23222643.
Further reading
- Bedford MT, Chan DC, Leder P (May 1997). "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands". The EMBO Journal. 16 (9): 2376–83. doi:10.1093/emboj/16.9.2376. PMC 1169838. PMID 9171351.