Effector-triggered immunity

Effector triggered immunity (ETI) is a property of the innate immune system. ETI was first identified in plants[1][2] but has also been identified in animal cells.[3]

The innate immune system is common to all multicellular organisms and forms the first line of defence against pathogens. Infected cells recognize that they are under attack by detecting the pathogen directly through the Microbe Associated Molecular Patterns (MAMPS) which bind with the Pattern Recognition Receptors (PRR) on the host cells. Host cells also recognize the pathogen through Effector Triggered Immunity (ETI),[4] whereby the host cells are alerted to the pathogen by the associated damage caused by pathogenic toxins or effectors.

The host cell detects the presence of the pathogen directly from the molecular patterns on the pathogen and indirectly through the damage caused to the host cell by the toxins generated by the pathogen.

References

  1. ↑ Spoel, SH (February 2012). "How do plants achieve immunity? Defence without specialized immune cells.". Nature Reviews Immunology. 12: 89–100. doi:10.1038/nri3141. PMID 22273771.
  2. ↑ Gassmann, Walter; Bhattacharjee, Saikat. "Effector-Triggered Immunity Signaling: From Gene-for-Gene Pathways to Protein-Protein Interaction Networks". Molecular Plant-Microbe Interactions. 25 (7): 862–868. doi:10.1094/MPMI-01-12-0024-IA.
  3. ↑ Stuart, Lynda M.; Paquette, Nicholas; Boyer, Laurent (15 February 2013). "Effector-triggered versus pattern-triggered immunity: how animals sense pathogens". Nature Reviews Immunology. 13 (3): 199–206. doi:10.1038/nri3398.
  4. ↑ Rajamuthiah, Rajmohan (May 2014). "Effector triggered immunity: Activation of innate immunity in metazoans by bacterial effectors". Virulence. 5: 697–702. doi:10.4161/viru.29091. PMC 4189875Freely accessible. PMID 25513770.
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