GMP reductase

guanosine monophosphate reductase

Identifiers
Symbol	GMPR
Entrez	2766
HUGO	4376
OMIM	139265
RefSeq	NM_006877
UniProt	P36959
Other data
EC number	1.7.1.7
Locus	Chr. 6 p23

guanosine monophosphate reductase 2
Identifiers
Symbol	GMPR2
Entrez	51292
HUGO	4377
OMIM	610781
RefSeq	NM_016576
UniProt	Q9P2T1
Other data
Locus	Chr. 14 q11.2

GMP reductase EC 1.7.1.7 (Guanosine 5'-monophosphate oxidoreductase ) is an enzyme that catalyses the irreversible and NADPH-dependent reductive deamination of GMP into IMP.^[1]

It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides.

In melanocytic cells, GMP reductase gene expression may be regulated by MITF.^[2]

References

↑ Andrews SC, Guest JR (Oct 1988). "Nucleotide sequence of the gene encoding the GMP reductase of Escherichia coli K12". The Biochemical Journal. 255 (1): 35–43. doi:10.1042/bj2550035. PMC 1135187. PMID 2904262.
↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

GMP reductase at the US National Library of Medicine Medical Subject Headings (MeSH)

Anabolism

R5P→IMP:	Ribose-phosphate diphosphokinase Amidophosphoribosyltransferase Phosphoribosylglycinamide formyltransferase AIR synthetase (FGAM cyclase) Phosphoribosylaminoimidazole carboxylase Phosphoribosylaminoimidazolesuccinocarboxamide synthase IMP synthase

IMP→AMP:	Adenylosuccinate synthase Adenylosuccinate lyase reverse AMP deaminase

IMP→GMP:	IMP dehydrogenase GMP synthase reverse GMP reductase

Catabolism

Anabolism

CAD Carbamoyl phosphate synthase II Aspartate carbamoyltransferase Dihydroorotase

Dihydroorotate dehydrogenase Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase

CTP synthetase

Catabolism

Oxidoreductases: nitrogenous donor (EC 1.7)

1.7.1	GMP reductase

1.7.2	Nitrite reductase (NO-forming)

1.7.3	Urate oxidase

1.7.7	Ferredoxin—nitrite reductase

1.7.99	Hydroxylamine reductase

This article incorporates text from the public domain Pfam and InterPro IPR001093

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