Cholate—CoA ligase
| Cholate—CoA ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 6.2.1.7 | ||||||||
| CAS number | 9027-90-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Cholate—CoA ligase (EC 6.2.1.7, BAL, bile acid CoA ligase, bile acid coenzyme A ligase, choloyl-CoA synthetase, choloyl coenzyme A synthetase, cholic thiokinase, cholate thiokinase, cholic acid:CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase, THCA-CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate—CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming), cholyl-CoA synthetase, trihydroxycoprostanoyl-CoA synthetase) is an enzyme with systematic name cholate:CoA ligase (AMP-forming).[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- (1) ATP + cholate + CoA AMP + diphosphate + choloyl-CoA
- (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
This enzyme requires Mg2+ for activity.
References
- ↑ Elliott, W.H. (1956). "The enzymic activation of cholic acid by guinea-pig-liver microsomes". Biochem. J. 62 (3): 427–433. PMID 13303991.
- ↑ Elliott, W.H. (1957). "The breakdown of adenosine triphosphate accompanying cholic acid activation by guinea-pig liver microsomes". Biochem. J. 65 (2): 315–321. PMID 13403911.
- ↑ Prydz, K.; Kase, B.F.; Björkhem, I.; Pedersen, J.I. (1988). "Subcellular localization of 3α,7α-dihydroxy- and 3α,7α,12α-trihydroxy-5β-cholestanoyl-coenzyme A ligase(s) in rat liver". J. Lipid Res. 29 (8): 997–1004. PMID 3183523.
- ↑ Schepers, L.; Casteels, M.; Verheyden, K.; Parmentier, G.; Asselberghs, S.; Eyssen, H.J.; Mannaerts, G.P. (1989). "Subcellular distribution and characteristics of trihydroxycoprostanoyl-CoA synthetase in rat liver". Biochem. J. 257 (1): 221–229. PMID 2521999.
- ↑ Mallonee, D.H.; Adams, J.L.; Hylemon, P.B. (1992). "The bile acid-inducible baiB gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A ligase". J. Bacteriol. 174 (7): 2065–2071. PMID 1551828.
- ↑ Wheeler, J.B.; Shaw, D.R.; Barnes, S. (1997). "Purification and characterization of a rat liver bile acid coenzyme A ligase from rat liver microsomes". Arch. Biochem. Biophys. 348 (1): 15–24. doi:10.1006/abbi.1997.0391. PMID 9390170.
- ↑ Falany, C.N.; Xie, X.; Wheeler, J.B.; Wang, J.; Smith, M.; He, D.; Barnes, S. (2002). "Molecular cloning and expression of rat liver bile acid CoA ligase". J. Lipid Res. 43: 2062–2071. doi:10.1194/jlr.M200260-JLR200. PMID 12454267.
External links
- Cholate---CoA ligase at the US National Library of Medicine Medical Subject Headings (MeSH)