Carboxycyclophosphamide
Names | |
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IUPAC name
3-({amino[bis(2-chloroethyl)amino]phosphoryl}oxy)propanoic acid | |
Other names
Carboxyphosphamide | |
Identifiers | |
22788-18-7 | |
3D model (Jmol) | Interactive image |
ChemSpider | 29229 |
PubChem | 31515 |
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Properties | |
C7H15Cl2N2O4P | |
Molar mass | 293.084762 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
Carboxycyclophosphamide is an inactive metabolite of the cytotoxic antineoplastic drug cyclophosphamide. In the metabolic pathway of cyclophosphamide inactivation it first metabolizes to 4-hydroxycyclophosphamide, then partially tautomerizes into aldophosphamide. Aldophosphamide then, in turn, is oxidized into carboxycyclophosphamide by the enzyme ALDH (aldehyde dehydrogenase).[1]
References
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