CHRNA3

CHRNA3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases CHRNA3, LNCR2, NACHRA3, PAOD2, cholinergic receptor nicotinic alpha 3 subunit
External IDs MGI: 87887 HomoloGene: 591 GeneCards: CHRNA3
Genetically Related Diseases
chronic obstructive pulmonary disease, obesity[1]
Targeted by Drug
hexamethonium, mecamylamine[2]
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

1136

110834

Ensembl

ENSG00000080644

ENSMUSG00000032303

UniProt

P32297

Q8R4G9

RefSeq (mRNA)

NM_000743
NM_001166694

NM_145129

RefSeq (protein)

NP_000734.2
NP_001160166.1

NP_660111.2

Location (UCSC) Chr 15: 78.59 – 78.62 Mb Chr 9: 55.01 – 55.03 Mb
PubMed search [3] [4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-3 is a protein that in humans is encoded by the CHRNA3 gene.[5][6]

Interactive pathway map

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NicotineActivityonChromaffinCells_WP1603 Go to article go to article Go to article Go to article Go to article Go to article go to article go to article Go to article Go to article go to article Go to article Go to article

|{{{bSize}}}px|alt=Nicotine Activity on Chromaffin Cells edit]]

Nicotine Activity on Chromaffin Cells edit

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    NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article

    |{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]

    Nicotine Activity on Dopaminergic Neurons edit

      See also

      References

      1. ↑ "Diseases that are genetically associated with CHRNA3 view/edit references on wikidata".
      2. ↑ "Drugs that physically interact with Neuronal acetylcholine receptor subunit alpha-3 view/edit references on wikidata".
      3. ↑ "Human PubMed Reference:".
      4. ↑ "Mouse PubMed Reference:".
      5. ↑ Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (Apr 1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics. 9 (2): 278–82. doi:10.1016/0888-7543(91)90253-B. PMID 2004777.
      6. ↑ "Entrez Gene: CHRNA3 cholinergic receptor, nicotinic, alpha 3".

      Further reading

      • Raimondi E, Rubboli F, Moralli D, et al. (1992). "Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits.". Genomics. 12 (4): 849–50. doi:10.1016/0888-7543(92)90324-L. PMID 1572664. 
      • Boulter J, O'Shea-Greenfield A, Duvoisin RM, et al. (1990). "Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster.". J. Biol. Chem. 265 (8): 4472–82. PMID 1689727. 
      • Papke RL, Heinemann SF (1992). "The role of the beta 4-subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine alpha 3-receptors.". J. Physiol. (Lond.). 440: 95–112. PMC 1180142Freely accessible. PMID 1725184. 
      • Mihovilovic M, Roses AD (1991). "Expression of mRNAs in human thymus coding for the alpha 3 subunit of a neuronal acetylcholine receptor.". Exp. Neurol. 111 (2): 175–80. doi:10.1016/0014-4886(91)90004-V. PMID 1989896. 
      • Fornasari D, Chini B, Tarroni P, Clementi F (1990). "Molecular cloning of human neuronal nicotinic receptor alpha 3-subunit.". Neurosci. Lett. 111 (3): 351–6. doi:10.1016/0304-3940(90)90287-J. PMID 2336208. 
      • Grando SA, Horton RM, Pereira EF, et al. (1996). "A nicotinic acetylcholine receptor regulating cell adhesion and motility is expressed in human keratinocytes.". J. Invest. Dermatol. 105 (6): 774–81. doi:10.1111/1523-1747.ep12325606. PMID 7490471. 
      • Rubboli F, Court JA, Sala C, et al. (1995). "Distribution of nicotinic receptors in the human hippocampus and thalamus.". Eur. J. Neurosci. 6 (10): 1596–604. doi:10.1111/j.1460-9568.1994.tb00550.x. PMID 7850023. 
      • Hiemke C, Stolp M, Reuss S, et al. (1997). "Expression of alpha subunit genes of nicotinic acetylcholine receptors in human lymphocytes.". Neurosci. Lett. 214 (2-3): 171–4. doi:10.1016/0304-3940(96)12908-6. PMID 8878111. 
      • Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617. 
      • Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.". FEBS Lett. 400 (3): 309–14. doi:10.1016/S0014-5793(96)01383-X. PMID 9009220. 
      • Zia S, Ndoye A, Nguyen VT, Grando SA (1998). "Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells.". Res. Commun. Mol. Pathol. Pharmacol. 97 (3): 243–62. PMID 9387186. 
      • Groot-Kormelink PJ, Luyten WH, Colquhoun D, Sivilotti LG (1998). "A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor.". J. Biol. Chem. 273 (25): 15317–20. doi:10.1074/jbc.273.25.15317. PMID 9624109. 
      • Maus AD, Pereira EF, Karachunski PI, et al. (1998). "Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors.". Mol. Pharmacol. 54 (5): 779–88. PMID 9804613. 
      • Rempel N, Heyers S, Engels H, et al. (1999). "The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3).". Hum. Genet. 103 (6): 645–53. doi:10.1007/s004390050885. PMID 9921897. 
      • Hellström-Lindahl E, Mousavi M, Zhang X, et al. (1999). "Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain.". Brain Res. Mol. Brain Res. 66 (1-2): 94–103. doi:10.1016/S0169-328X(99)00030-3. PMID 10095081. 
      • Sato KZ, Fujii T, Watanabe Y, et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines.". Neurosci. Lett. 266 (1): 17–20. doi:10.1016/S0304-3940(99)00259-1. PMID 10336173. 
      • Flora A, Schulz R, Benfante R, et al. (2000). "Transcriptional regulation of the human alpha5 nicotinic receptor subunit gene in neuronal and non-neuronal tissues.". Eur. J. Pharmacol. 393 (1-3): 85–95. doi:10.1016/S0014-2999(00)00040-6. PMID 10771001. 
      • Boorman JP, Groot-Kormelink PJ, Sivilotti LG (2001). "Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes.". J. Physiol. (Lond.). 529 (3): 565–77. doi:10.1111/j.1469-7793.2000.00565.x. PMC 2270211Freely accessible. PMID 11118490. 
      • Lev-Lehman E, Bercovich D, Xu W, et al. (2001). "Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4.". J. Hum. Genet. 46 (7): 362–6. doi:10.1007/PL00010921. PMID 11450844. 

      External links

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