Colorectal polyp

Colon polyps
Polyp of sigmoid colon as revealed by colonoscopy. Approximately 1 cm in diameter. The polyp was removed by snare cautery
Classification and external resources
Specialty gastroenterology
ICD-10 K63.5 & various
MedlinePlus 000266
eMedicine med/414
MeSH C23.300.825
Gross appearance of a colectomy specimen containing two colorectal polyps and one invasive colorectal carcinoma
Micrograph of a tubular adenoma, the most common type of dysplastic polyp in the colon.
Micrograph of a sessile serrated adenoma. H&E stain.
Micrograph of a Peutz-Jeghers colonic polyp - a type of hamartomatous polyp. H&E stain.
Micrograph of a tubular adenoma – dysplastic epithelium (dark purple) on left of image; normal epithelium (blue) on right. H&E stain.
Micrograph of a villous adenoma. These polyps are considered to have a high risk of malignant transformation. H&E stain.

A colorectal polyp is a polyp (fleshy growth) occurring on the lining of the colon or rectum.[1] Untreated colorectal polyps can develop into colorectal cancer.[2]

Colorectal polyps are often classified by their behaviour (i.e. benign vs. malignant) and/or etiology (e.g. as a consequence of inflammatory bowel disease). They may be benign (e.g. hyperplastic polyp), pre-malignant (e.g. tubular adenoma) or malignant (e.g. colorectal adenocarcinoma).

Types

The most common general classification is:

Hyperplastic polyp

Most hyperplastic polyps are found in the distal colon and rectum.[3] They have no malignant potential,[3] which means that they are no more likely than normal tissue to eventually become a cancer.

Hyperplastic polyps are serrated polyps. Hyperplastic polyps have three histologic patterns of growth: microvesicular, goblet cell and mucin poor.

Hyperplastic polyposis syndrome is a rare condition that has been defined by the World Health Organization as either:

  1. Five or more hyperplastic polyps proximal to the sigmoid colon, with two polyps greater than 10mm in diameter; or
  2. Any number of hyperplastic polyps proximal to the sigmoid colon in a person with a first degree relative who has hyperplastic polyposis syndrome; or
  3. More than 30 hyperplastic polyps of any size throughout the colon and rectum.[4]

Although thought to exhibit no malignant potential it has been shown that hyperplastic polyps on the right side of the colon do exhibit a malignant potential. This occurs through multiple mutations which affect the DNA-mismatch-repair pathways. As such DNA mutations during replication are not repaired. This leads to microsatellite instability which can eventually lead to malignant transformation in polyps on the right side of the colon.

Neoplastic polyp

A neoplasm is a tissue whose cells have lost its normal differentiation. They can be either benign growths or malignant growths. The malignant growths can either have primary or secondary causes.

Adenomas

Neoplastic polyps of the bowel are often benign hence called adenomas. An adenoma is tumor glandular tissue, that has not (yet) gained the properties of a cancer.

The common adenomas of the colon (colorectal adenoma) are the tubular, tubulovillous, villous, and sessile serrated (SSA).[3]

As is evident from their name, sessile serrated and traditional serrated adenomas (TSAs) have a serrated appearance and can be difficult to distinguish microscopically from hyperplastic polyps.[3] Making this distinction is important, however, since SSAs and TSAs have the potential to become cancers,[4] while hyperplastic polyps do not.[3]

The villous subdivision are associated with the highest malignant potential because they generally have the largest surface area. (This is because the villi are projections into the lumen and hence have a bigger surface area.) However, villous adenomas are no more likely than tubular or tubulovillous adenomas to become cancerous if their sizes are all the same.[3]

Hamartomatous polyp

They are growths, like tumours found in organs as a result of faulty development. They are normally made up of a mixture of tissues. They contain mucus-filled glands, with retention cysts, abundant connective tissue, and a chronic cellular infiltration of eosinophils.[5] They grow at the normal rate of the host tissue and rarely cause problems such as compression. A common example of a hamartomatous lesion is a strawberry naevus. Hamartomatous polyps are often found by chance; occurring in syndromes such as Peutz-Jegher Syndrome or Juvenile Polyposis Syndrome.

Peutz-Jeghers syndrome is associated with polyps of the GI tract and also increased pigmentation around the lips, genitalia, buccal mucosa feet and hands. People are often diagnosed with Peutz-Jegher after presenting at around the age of 9 with an intussusception. The polyps themselves carry little malignant potential but because of potential coexisting adenomas there is a 15% chance of colonic malignancy.

Juvenile polyps are hamartomatous polyps which often become evident before twenty years of age, but can also be seen in adults. They are usually solitary polyps found in the rectum which most commonly present with rectal bleeding. Juvenile polyposis syndrome is characterised by the presence of more than five polyps in the colon or rectum, or numerous juvenile polyps throughout the gastrointestinal tract, or any number of juvenile polyps in any person with a family history of juvenile polyposis. People with juvenile polyposis have an increased risk of colon cancer.[4]

Inflammatory polyp

These are polyps which are associated with inflammatory conditions such as Ulcerative Colitis and Crohns disease.

Symptoms

Colorectal polyps are not usually associated with symptoms.[2] When they occur, symptoms include rectal bleeding, bloody stools, abdominal pain and fatigue.[2] A change in bowel habits may occur including constipation and diarrhoea.[6] Occasionally, if a polyp is big enough to cause a bowel obstruction, there may be nausea, vomiting and severe constipation.[6]

Screening and diagnosis

Colorectal polyps can be detected using a faecal occult blood test, flexible sigmoidoscopy, colonoscopy, virtual colonoscopy, digital rectal examination, barium enema or a pill camera.[6]

When does a polyp become a problem?

Malignant potential is associated with

Normally an adenoma which is greater than 0.5 cm is treated

Prevention

Diet and lifestyle are believed to play a large role in whether colorectal polyps form. Studies show there to be a protective link between consumption of cooked green vegetables, brown rice, legumes, and dried fruit and decreased incidence of colorectal polyps.[7]

Treatment

Polyps can be removed during a colonoscopy or sigmoidoscopy using a wire loop that cuts the stalk of the polyp and cauterises it to prevent bleeding.[6] Many "defiant" polyps—large, flat, and otherwise laterally spreading adenomas—may be removed endoscopically by a technique called endoscopic mucosal resection (EMR), which involves injection of fluid underneath the lesion to lift it and thus facilitate surgical excision. These techniques may be employed as an alternative to a much-more-invasive colectomy.[8]

Structure

Polyps are either pedunculated (attached to the intestinal wall by a stalk) or sessile (grow directly from the wall).[9]

See also

Additional images

References

  1. ↑ Santero, Michael; Dennis Lee (2005-03-25). "Colon polyp symptoms, diagnosis and treatment". MedicineNet.com. Retrieved 2007-10-25.
  2. 1 2 3 Lehrer, Jenifer K. (2006-07-25). "Colorectal polyps". MedlinePlus. Retrieved 2007-10-25.
  3. 1 2 3 4 5 6 Kumar, Vinay (2010). "17 - Polyps". Robbins and Cotran pathologic basis of disease. (8th ed.). Philadelphia, PA: Saunders/Elsevier. ISBN 978-1-4160-3121-5.
  4. 1 2 3 Stoler, Mark A.; Mills, Stacey E.; Carter, Darryl; Joel K Greenson; Reuter, Victor E. (2009). Sternberg's Diagnostic Surgical Pathology. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-7942-1.
  5. ↑ HAMARTOMATOUS POLYPOSIS SYNDROMES, Surg Clin North Am. Author manuscript; available in PMC 2009 August 1.
  6. 1 2 3 4 "Colon polyps". Mayo Clinic. 2007-07-16. Retrieved 2007-10-25.
  7. ↑ Tantamango, Yessenia M.; Knutsen, Synnove F.; Beeson, W. Lawrence; Fraser, Gary; Sabate, Joan (2011-01-01). "Foods and food groups associated with the incidence of colorectal polyps: the Adventist Health Study". Nutrition and Cancer. 63 (4): 565–572. doi:10.1080/01635581.2011.551988. ISSN 1532-7914. PMC 3427008Freely accessible. PMID 21547850.
  8. ↑ "How I Do It" — Removing large or sessile colonic polyps. Brian Saunders; St. Mark’s Academic Institute; Harrow, Middlesex, UK. Retrieved April 9, 2008.
  9. ↑ Classen, Meinhard; G. N. J. Tytgat; Charles J. Lightdale (2002). Gastroenterological Endoscopy. Thieme. p. 303. ISBN 1-58890-013-4.
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