Artemisinic aldehyde Delta11(13)-reductase

Artemisinic aldehyde Delta11(13)-reductase (EC 1.3.1.92, Dbr2) is an enzyme with systematic name artemisinic aldehyde:NADP⁺ oxidoreductase.^[1]^[2] This enzyme catalyses the following chemical reaction

(11R)-dihydroartemisinic aldehyde + NADP⁺

\rightleftharpoons

artemisinic aldehyde + NADPH + H⁺

This enzyme i present in Artemisia annua.

References

↑ Bertea, C.M.; Freije, J.R.; van der Woude, H.; Verstappen, F.W.; Perk, L.; Marquez, V.; De Kraker, J.W.; Posthumus, M.A.; Jansen, B.J.; de Groot, A.; Franssen, M.C.; Bouwmeester, H.J. (2005). "Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua". Planta Med. 71 (1): 40–47. doi:10.1055/s-2005-837749. PMID 15678372.
↑ Zhang, Y.; Teoh, K.H.; Reed, D.W.; Maes, L.; Goossens, A.; Olson, D.J.; Ross, A.R.; Covello, P.S. (2008). "The molecular cloning of artemisinic aldehyde Δ¹¹⁽¹³⁾ reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua". J. Biol. Chem. 283 (31): 21501–21508. doi:10.1074/jbc.M803090200. PMID 18495659.

Oxidoreductases: CH–CH oxidoreductases (EC 1.3)

1.3.1: NAD/NADP acceptor	Enoyl-acyl carrier protein reductase/Enoyl ACP reductase 7-Dehydrocholesterol reductase Biliverdin reductase 2,4 Dienoyl-CoA reductase Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase

1.3.3: Oxygen acceptor	Dihydroorotate dehydrogenase Coproporphyrinogen III oxidase Protoporphyrinogen oxidase Bilirubin oxidase Acyl-CoA oxidase Dihydrouracil oxidase Tetrahydroberberine oxidase Secologanin synthase Tryptophan alpha,beta-oxidase Pyrroloquinoline-quinone synthase L-galactonolactone oxidase

1.3.5: Quinone	Succinate dehydrogenase SDHA SDHB SDHC SDHD

1.3.99: Other acceptors	Fumarate reductase Butyryl-CoA dehydrogenase Acyl CoA dehydrogenase ACADSB ACADS 5α-reductase SRD5A1 SRD5A2 SRD5A3 Glutaryl-CoA dehydrogenase Isovaleryl coenzyme A dehydrogenase 3-oxo-5beta-steroid 4-dehydrogenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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