Anti-sp100 antibodies

Schematic representation of antibody.

Anti-sp100 antibodies are found in association with primary biliary cirrhosis.^[1] The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis. 20-30% of patients suffering from primary biliary cirrhosis have sp100 Abs. The sera of these patients exhibit a characteristic "nuclear dots" pattern in indirect immunofluorescence (IIF) on Hep-2 cells.

Immunodominant regions of sp100

Antigenic region 1 - positions 296-311 - Sequence (I K K E K P F S N S K V E C Q A)
Antigenic region 2 - positions 332-351 - Sequence (E G S T D V D E P L E V F I S A P R S E)

(Bolded areas represent the core epitope.)^[2]

References

↑ Szostecki C, Guldner HH, Netter HJ, Will H (1990). "Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis". J. Immunol. 145 (12): 4338–47. PMID 2258622.
↑ Blüthner M, Schäfer C, Schneider C, Bautz FA (1999). "Identification of major linear epitopes on the sp100 nuclear PBC autoantigen by the gene-fragment phage-display technology". Autoimmunity. 29 (1): 33–42. doi:10.3109/08916939908995970. PMID 10052683.

Medical test: Antibodies: autoantibodies

Anti-nuclear antibody	PBC: Anti-gp210 Anti-p62 Anti-sp100 ENA: Anti-topoisomerase/Scl-70 Anti-Jo1 ENA4 Anti-Sm Anti-nRNP Anti-Ro Anti-La Anti-centromere Anti-dsDNA

Anti-mitochondrial antibody	Anti-cardiolipin

Anti-cytoplasm antibody	Anti-neutrophil cytoplasmic C-ANCA P-ANCA Anti-smooth muscle Anti-actin Anti-TPO/Antimicrosomal

Cell membrane	Anti-ganglioside Anti-GBM Anti-glutamate

Extracellular	Anti-thrombin Lupus anticoagulant Coeliac disease: Anti-transglutaminase Anti-gliadin not autoantibody RA Rheumatoid factor/anti-IgG Anti-citrullinated peptide

Multiple locations	Anti-phospholipid Anti-apolipoprotein

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