ACP-SH:acetate ligase

ACP-SH:acetate ligase (EC 6.2.1.35, HS-acyl-carrier protein:acetate ligase, [acyl-carrier protein]:acetate ligase, MadH) is an enzyme with systematic name acetate:(acyl-carrier-protein) ligase (AMP-forming).^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

ATP + acetate + an [acyl-carrier protein]

\rightleftharpoons

AMP + diphosphate + an acetyl-[acyl-carrier protein]

This enzyme, from the anaerobic bacterium Malonomonas rubra, is a component of the multienzyme complex EC 4.1.1.89, biotin-dependent malonate decarboxylase.

References

↑ Hilbi, H.; Dehning, I.; Schink, B.; Dimroth, P. (1992). "Malonate decarboxylase of Malonomonas rubra, a novel type of biotin-containing acetyl enzyme". Eur. J. Biochem. 207: 117–123. doi:10.1111/j.1432-1033.1992.tb17028.x. PMID 1628643.
↑ Berg, M.; Hilbi, H.; Dimroth, P. (1996). "The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2′-(5"-phosphoribosyl)-3′-dephosphocoenzyme A as a prosthetic group". Biochemistry. 35: 4689–4696. doi:10.1021/bi952873p. PMID 8664258.
↑ Berg, M.; Hilbi, H.; Dimroth, P. (1997). "Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na⁺ pump and evidence for their function". Eur. J. Biochem. 245: 103–115. doi:10.1111/j.1432-1033.1997.00103.x. PMID 9128730.
↑ Dimroth, P.; Hilbi, H. (1997). "Enzymic and genetic basis for bacterial growth on malonate". Mol. Microbiol. 25: 3–10. doi:10.1046/j.1365-2958.1997.4611824.x. PMID 11902724.

External links

ACP-SH:acetate ligase at the US National Library of Medicine Medical Subject Headings (MeSH)

Enzymes: CO CS and CN ligases (EC 6.1-6.3)

6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanine Arginine Asparagine Aspartate Cysteine D-alanine—poly(phosphoribitol) ligase Glutamate Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine

6.2: Carbon-Sulfur	Succinyl coenzyme A synthetase Acetyl—CoA synthetase Long-chain-fatty-acid—CoA ligase

6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

This article is issued from Wikipedia - version of the 5/16/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.