2-hydroxyethylphosphonate dioxygenase
| 2-hydroxyethylphosphonate dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.13.11.72 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
2-hydroxyethylphosphonate dioxygenase (EC 1.13.11.72, HEPD, phpD (gene)) is an enzyme with systematic name 2-hydroxyethylphosphonate:O2 1,2-oxidoreductase (hydroxymethylphosphonate forming).[1][2][3] This enzyme catalyses the following chemical reaction
- 2-hydroxyethylphosphonate + O2 hydroxymethylphosphonate + formate
2-hydroxyethylphosphonate dioxygenase contains non-heme-Fe(II).
References
- ↑ Cicchillo, R.M.; Zhang, H.; Blodgett, J.A.; Whitteck, J.T.; Li, G.; Nair, S.K.; van der Donk, W.A.; Metcalf, W.W. (2009). "An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis". Nature. 459 (7248): 871–874. doi:10.1038/nature07972. PMC 2874955
. PMID 19516340. - ↑ Whitteck, J.T.; Malova, P.; Peck, S.C.; Cicchillo, R.M.; Hammerschmidt, F.; van der Donk, W.A. (2011). "On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase". J. Am. Chem. Soc. 133 (12): 4236–4239. doi:10.1021/ja1113326. PMC 3069692. PMID 21381767.
- ↑ Peck, S.C.; Cooke, H.A.; Cicchillo, R.M.; Malova, P.; Hammerschmidt, F.; Nair, S.K.; van der Donk, W.A. (2011). "Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase". Biochemistry. 50 (30): 6598–6605. doi:10.1021/bi200804r. PMC 3143709. PMID 21711001.
External links
- 2-hydroxyethylphosphonate dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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